File:Mechanisms of TET-mediated transcription.jpg
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Figure 5. Mechanisms of TET-mediated transcription. (a) The canonical regulation of TET-mediated transcription relies on its dioxygenase activity, which turns 5mC into 5hmC; (b) A subset of TET proteins can recruit repressor complexes, such as PRC and Sin3A/HDAC, whereas a great proportion of TET proteins are found to bind to the CpG islands of TSS. As in the case of ES cells, TET enacts the dual functions by facilitating transcription of pluripotency factors via DNA demethylation and transcriptionally repressing developmental regulators; (c) TET proteins also act as a co-activator under hypoxia. TET proteins are associated with HIF-1α and CBP proteins at the HRE of a set of metabolic genes, e.g., INSIG1. TET can also interact with OGT at TSS. This leads to histone 2B Ser112 GlcNAc, and it further facilitates its monoubiquitination [91 ], presumably activating transcription. PRC: Polycomb repressive complex; HDAC: histone deacetylase; HRE: hypoxia-response element; OGT: O-GlcNAc transferase |
| Date | |
| Source | https://www.researchgate.net/publication/293042602_Hypoxia_Epithelial-Mesenchymal_Transition_and_TET-Mediated_Epigenetic_Changes Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes Journal of Clinical Medicine February 20165(2):24 DOI:10.3390/jcm5020024 |
| Author | Shih-Han Kao, Kou-Juey Wu and Wen-Hwa Lee |
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© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
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| current | 19:59, 20 May 2024 | | 718 × 531 (168 KB) | Rasbak (talk | contribs) | {{Information |description= Figure 5. Mechanisms of TET-mediated transcription. (a) The canonical regulation of TET-mediated transcription relies on its dioxygenase activity, which turns 5mC into 5hmC; (b) A subset of TET proteins can recruit repressor complexes, such as PRC and Sin3A/HDAC, whereas a great proportion of TET proteins are found to bind to the CpG islands of TSS. As in the case of ES cells, TET enacts the dual functions by facilitating transcription of pluripotency factors via D... |
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