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Description1-s2.0-S0092867421008394-main.pdf |
English: The Middle East region is important to understand human evolution and migrations but is underrepresented in genomic studies. Here, we generated 137 high-coverage physically phased genome sequences from eight Middle Eastern populations using linked-read sequencing. We found no genetic traces of early expansions out-of-Africa in present-day populations but found Arabians have elevated Basal Eurasian ancestry that dilutes their Neanderthal ancestry. Population sizes within the region started diverging 15–20 kya, when Levantines expanded while Arabians maintained smaller populations that derived ancestry from local hunter-gatherers. Arabians suffered a population bottleneck around the aridification of Arabia 6 kya, while Levantines had a distinct bottleneck overlapping the 4.2 kya aridification event. We found an association between movement and admixture of populations in the region and the spread of Semitic languages. Finally, we identify variants that show evidence of selection, including polygenic selection. Our results provide detailed insights into the genomic and selective histories of the Middle East. |
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https://www.sciencedirect.com/science/article/pii/S0092867421008394 https://doi.org/10.1016/j.cell.2021.07.013 |
Author | Mohamed A. Almarri, Marc Haber, Reem A. Lootah, Pille Hallast, Saeed Al Turki, Hilary C. Martin, Yali Xue, Chris Tyler-Smith |
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current | 08:34, 5 August 2021 | 1,254 × 1,629, 29 pages (7.65 MB) | Pamputt (talk | contribs) | Uploaded a work by Mohamed A. Almarri, Marc Haber, Reem A. Lootah, Pille Hallast, Saeed Al Turki, Hilary C. Martin, Yali Xue, Chris Tyler-Smith from https://www.sciencedirect.com/science/article/pii/S0092867421008394 https://doi.org/10.1016/j.cell.2021.07.013 with UploadWizard |
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Short title | The genomic history of the Middle East |
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Image title | Cell, Corrected proof. doi:10.1016/j.cell.2021.07.013 |
Author | Mohamed A. Almarri |
Software used | Elsevier |
Conversion program | Acrobat Distiller 8.1.0 (Windows) |
Encrypted | no |
Page size | 602.986 x 782.986 pts |
Version of PDF format | 1.7 |