File:A-SEL1L-Mutation-Links-a-Canine-Progressive-Early-Onset-Cerebellar-Ataxia-to-the-Endoplasmic-pgen.1002759.s007.ogv

A-SEL1L-Mutation-Links-a-Canine-Progressive-Early-Onset-Cerebellar-Ataxia-to-the-Endoplasmic-pgen.1002759.s007.ogv(Ogg multiplexed audio/video file, Theora/Vorbis, length 1 min 37 s, 640 × 480 pixels, 1.71 Mbps overall, file size: 19.73 MB)

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English: Gait. Video shows the normal gait of an unaffected three months old Finnish Hound puppy and the altered gait of two affected similarly aged puppies. Note the difficulty of the affected puppies to control limb movements (ataxia), particularly in the hind limbs. Affected puppies present with swaying of the whole body (truncal ataxia) and abnormal postures, which are caused by the coordination difficulties. The puppies struggle with movement coordination, especially when the direction or speed of the movement changes or when the movement is initiated or stops abruptly. This is caused by inability to control the distance and scale of the movement (dysmetria), which leads to too short or too long steps.
Date
Source Video S1 from Kyöstilä K, Cizinauskas S, Seppälä E, Suhonen E, Jeserevics J, Sukura A, Syrjä P, Lohi H (2012). "A SEL1L Mutation Links a Canine Progressive Early-Onset Cerebellar Ataxia to the Endoplasmic Reticulum–Associated Protein Degradation (ERAD) Machinery". PLOS Genetics. DOI:10.1371/journal.pgen.1002759. PMID 22719266. PMC: 3375262.
Author Kyöstilä K, Cizinauskas S, Seppälä E, Suhonen E, Jeserevics J, Sukura A, Syrjä P, Lohi H
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Date/TimeThumbnailDimensionsUserComment
current06:05, 31 October 20121 min 37 s, 640 × 480 (19.73 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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Format Bitrate Download Status Encode time
VP9 480P 821 kbps Completed 22:09, 15 August 2018 1 min 49 s
Streaming 480p (VP9) 818 kbps Completed 03:58, 17 December 2023 2.0 s
VP9 360P 456 kbps Completed 22:08, 15 August 2018 1 min 30 s
Streaming 360p (VP9) 452 kbps Completed 17:46, 17 December 2023 2.0 s
VP9 240P 264 kbps Completed 22:08, 15 August 2018 1 min 17 s
Streaming 240p (VP9) 260 kbps Completed 05:46, 9 December 2023 1.0 s
WebM 360P 498 kbps Completed 16:55, 9 November 2012 2 min 21 s
Streaming 144p (MJPEG) 844 kbps Completed 08:59, 29 October 2023 3.0 s
Stereo (Opus) 2 kbps Completed 20:20, 12 November 2023 1.0 s
Stereo (MP3) 128 kbps Completed 01:17, 29 October 2023 2.0 s

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