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File:Biocontainment by control over essential genes.jpg

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From the study "Safety by design: Biosafety and biosecurity in the age of synthetic genomics"

Summary edit

Description
English: "Control can be attained by independent systems at different points along the flow of genetic information, allowing the free combination of different systems. (1) Recombinational switches lead to the excision of essential genes in restrictive conditions. (2) Transcriptional switches drive expression of essential proteins only if specific chemical inducers are available. (3) Post-translational switches direct essential proteins for degradation, leading to cell death unless a ligand is supplied. (4) Genetic code expansion can be leveraged to make cell survival dependent on the exogenous supply of a non-canonical amino acid."
Date
Source https://www.cell.com/iscience/fulltext/S2589-0042(23)00242-0
Author

Authors of the study: 

   Stefan A. Hoffmann
   James Diggans
   Douglas Densmore
   Junbiao Dai
   Tom Knight
   Emily Leproust
   Jef D. Boeke
   Nicole Wheeler
Yizhi Cai

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current16:08, 3 April 2023Thumbnail for version as of 16:08, 3 April 20232,923 × 2,837 (548 KB)Prototyperspective (talk | contribs)Uploaded a work by Authors of the study: Stefan A. Hoffmann James Diggans Douglas Densmore Junbiao Dai Tom Knight Emily Leproust Jef D. Boeke Nicole Wheeler Yizhi Cai from https://www.cell.com/iscience/fulltext/S2589-0042(23)00242-0 with UploadWizard

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