English: Probability distribution of subunits in configuration space during gating, when the membrane potential increased to +60 mV from a resting potential of −100 mV. Vertical dashed line is the assumed border between resting and activated conformations. The white vertical curve shows the flux within configuration space across this border. The net flux from the permissive state to the open state is shown by the arrow exiting the subunit configuration space at the top right corner. Open state probability is shown (color scale) in the square on the upper right and plotted as a function of time in the right bottom panel.