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File:DL20221125 hCG LHCGR cAMP.tif

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cAMP pathway activation and inhibition via G protein-coupled receptors

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Description
English: Ligand binding to GPCRs induces conformational change that causes dissociation of G_alpha subunits. The s-type G_alpha causes activation of adenylyl cyclase and the i-type of G_alpha causes inhibition of adenylyl cyclase. Activated adenylyl cyclase produces cAMP that can activate downstream effectors.
Eesti: Ligandi (näiteks gonadotropiini) seostumine retseptorile põhjustab viimases ruumilise struktuuri muutusi, mis kokkuvõttes viivad retseptoriga seotud G-valgu dissotsiatsioonini. Vabanenud G-valgu alaühikute eri tüübid võivad aktiveerida või inhibeerida ensüümi adenülaadi tsüklaas, mis vastutab tsüklilise adenosiinmonofosfaadi ehk cAMP tootmise eest. cAMP on sekundaarne virgatsaine, mis käivitab geeniekspressiooniga seotud signaaliradu rakkudes.
Date
Source Own work
Author Darja.Lavogina

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current13:34, 25 November 2022Thumbnail for version as of 13:34, 25 November 20226,955 × 4,837 (2.23 MB)Darja.Lavogina (talk | contribs)Uploaded own work with UploadWizard

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