File:Evaluation of Membrane Permeability of Copper-Based Drugs - norganics-11-00179.pdf
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DescriptionEvaluation of Membrane Permeability of Copper-Based Drugs - norganics-11-00179.pdf |
English: Membrane permeability of copper complexes were measured using an artificial membrane. H(555-N) and 6UH were found to increase the permeability of Cu 6.8 and 5.4 fold respectively. |
Date | |
Source | Own work |
Author | Evariste Umba |
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Short title | Evaluation of Membrane Permeability of Copper-Based Drugs |
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Image title | Membrane permeability of copper complexes with potential anti-inflammatory activity were measured using an artificial membrane in a modified Franz cell. Using CuCl2 as the control, all the ligands tested enhanced the diffusion of copper, with enhancement factors ranging from 2 to 7. Octanol/water partition coefficients (log Ko/w) were measured and correlated with the permeability coefficients (Kp). In addition, chemical speciation was used to determine the predominant complex in solution at physiological pH. No correlation was found between the measured permeability coefficients and either molecular weight (MW) or log Ko/w. |
Author | Evariste Umba-Tsumbu, Ahmed N. Hammouda and Graham Ellis Jackson |
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Software used | LaTeX with hyperref |
Conversion program | pdfTeX-1.40.21 |
Encrypted | no |
Page size | 595.276 x 841.89 pts (A4) |
Version of PDF format | 1.7 |