Identifier: examinationofu00saxe (find matches)
Title: Examination of the urine; a manual for students and practitioners
Year: 1909 (1900s)
Authors: Saxe, George Alexander De Santos, 1876-1911
Subjects: Urine
Publisher: Philadelphia and London, W. B. Saunders Company
Contributing Library: The Library of Congress
Digitizing Sponsor: The Library of Congress

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6,000 parts of cold waterand in 1600 parts of boiling water. Impure uric acid ismore readily soluble in water. It is not acid in reaction incold solutions when tested with litmus-paper. It is in-soluble in alcohol and ether, but soluble in warm glycerin,insoluble in strong mineral acids, but soluble in alkalis.It is more soluble in solutions of urea than in water.On boiling it reduces alkaline solutions of copper, firstgiving a white precipitate of cuprous urate. The Origin of Uric Acid.—As has already been saidin the definition of uric acid, this body is a product of oxi-dation of the nuclein bases. Horbaczewski regarded itespecially as derived from the nuclei of the leukocytes.It has been shown, however, that the other cells of the or-ganism containing nuclei and, therefore, nucleins, may alsobe the source of uric acid, and that, in fact, the leukocytesgive origin to a very small fraction of the uric acid output.The greatest source of uric acid are the nuclein or the purin PLATE 4
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Uric-acid Crystals; Normal Color (after Peyer), URIC ACID I47 compounds contained in the food. The amount of uricacid excreted is, indeed, to be measured only in the light ofour knowledge of the amount of nuclein-containing foodthat is eaten. The old idea that uric acid is derived from all proteidsof the food is wrong, for when very large amounts of proteidfood containing no nuclein are given, there is no increaseof uric acid. On the other hand, when large amounts ofnuclein are given in the food (organs containing manynucleated cells, like the pancreas, brain, etc.) there isalways an increase in the excretion of uric acid. The term endogenous uric acid is applied to the uricacid derived from the nucleins of body cells, while the termexogenous uric acid is used to designate that derived fromthe nucleins of the food. There is also a very small amountof uric acid formed synthetically in the body, as is the casein birds and in certain reptiles. In these animals uricacid is the chief nitro

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