File:Gastrointestinal stromal tumour - superf - intermed mag.jpg

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Intermediate magnification micrograph of a gastrointestinal stromal tumour, commonly abbreviated GIST. H&E stain.

GISTs arise from the interstitial cells of Cajal which are found between the layers of the muscularis propria;[1] thus, GISTs are typically centred on the muscularis propria.

The tumour classically consists of spindle cells; however, it may have epithelioid cells as in this case. The diagnosis is confirmed with (positive) immunostains (CD34 and CD117).

The main differential diagnosis is leiomyoma.

Related images

Spindle cell GIST:

References

  1. Agaimy A, Wünsch PH (August 2006). "Gastrointestinal stromal tumours: a regular origin in the muscularis propria, but an extremely diverse gross presentation. A review of 200 cases to critically re-evaluate the concept of so-called extra-gastrointestinal stromal tumours". Langenbecks Arch Surg 391 (4): 322–9. DOI:10.1007/s00423-005-0005-5. PMID 16402273.
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Author Nephron

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current01:32, 11 February 2013Thumbnail for version as of 01:32, 11 February 20132,848 × 4,272 (5.49 MB)Nephron (talk | contribs){{Information |Description= Intermediate magnification micrograph of a '''gastrointestinal stromal tumour''', commonly abbreviated '''GIST'''. H&E stain. GISTs arise from the [[w:i...