File:Increased-Vulnerability-of-Human-Ventricle-to-Re-entrant-Excitation-in-hERG-linked-Variant-1-Short-pcbi.1002313.s004.ogv
Increased-Vulnerability-of-Human-Ventricle-to-Re-entrant-Excitation-in-hERG-linked-Variant-1-Short-pcbi.1002313.s004.ogv (Ogg Theora video file, length 33 s, 529 × 333 pixels, 917 kbps, file size: 3.64 MB)
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DescriptionIncreased-Vulnerability-of-Human-Ventricle-to-Re-entrant-Excitation-in-hERG-linked-Variant-1-Short-pcbi.1002313.s004.ogv |
English: N588K reentry in realistic 2D geometry. Re-entrant spiral waves generated by the application of a premature S2 stimulus into the refractory and partially recovered region of an excitation wave after a delay of 241 ms rom the initial wave stimulus under the N588K (SQT1 mutant) condition. The induced spiral waves transition from transmural re-entry with tip rotating within the ventricle wall to anatomical re-entry with tip rotating around the ventricle boundary. The spiral waves persist under the SQT1 condition and break up forming regenerative multiple re-entrant wavelets. |
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Source | Video S4 from Adeniran I, McPate M, Witchel H, Hancox J, Zhang H (2011). "Increased Vulnerability of Human Ventricle to Re-entrant Excitation in hERG-linked Variant 1 Short QT Syndrome". PLOS Computational Biology. DOI:10.1371/journal.pcbi.1002313. PMID 22194679. PMC: 3240585. | ||
Author | Adeniran I, McPate M, Witchel H, Hancox J, Zhang H | ||
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current | 17:01, 30 October 2012 | 33 s, 529 × 333 (3.64 MB) | Open Access Media Importer Bot (talk | contribs) | Automatically uploaded media file from Open Access source. Please report problems or suggestions here. |
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Author | Adeniran I, McPate M, Witchel H, Hancox J, Zhang H |
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Usage terms | http://creativecommons.org/licenses/by/3.0/ |
Image title | N588K reentry in realistic 2D geometry. Re-entrant spiral waves generated by the application of a premature S2 stimulus into the refractory and partially recovered region of an excitation wave after a delay of 241 ms rom the initial wave stimulus under the N588K (SQT1 mutant) condition. The induced spiral waves transition from transmural re-entry with tip rotating within the ventricle wall to anatomical re-entry with tip rotating around the ventricle boundary. The spiral waves persist under the SQT1 condition and break up forming regenerative multiple re-entrant wavelets. |
Software used | Xiph.Org libtheora 1.1 20090822 (Thusnelda) |
Date and time of digitizing | 2011-12 |