File:MOC fibers and the cholinergic synapse onto OHCs in the mature Organ of Corti-B.svg
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DescriptionMOC fibers and the cholinergic synapse onto OHCs in the mature Organ of Corti-B.svg |
English: Schematics Showing the Central Origin (A) and Peripheral Projections (B) of the MOC Fibers and the Cholinergic Synapse onto OHCs in the Mature Organ of Corti (C) MOC efferent neurons are located in the superior olivary complex of the brainstem and project to the cochlea, where they make direct synaptic contacts at the base of the OHCs. At this synapse, ACh is released. It binds to α9α10 receptors present at the OHCs, leading to Ca2+ influx and the subsequent activation of Ca2+-dependent SK2 K+ channels and hair cell hyperpolarization. The black arrow in (A) indicates the place of electrical stimulation to activate the MOC fibers. The white arrow in (B) indicates the afferent fibers that bring the information from the IHCs to the central nervous system, and the red arrow indicates the MOC fibers. For approximately 10 d after birth (before the onset of hearing), cholinergic efferents temporarily synapse directly with IHCs (not shown in the figure) and provide a useful experimental target for the study of altered α9α10 receptors. |
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This is a retouched picture, which means that it has been digitally altered from its original version. Modifications: Isolated subfigure B and converted to png. The original can be viewed here: MOC fibers and the cholinergic synapse onto OHCs in the mature Organ of Corti.jpg: . Modifications made by Mike.lifeguard.
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This image is a derivative work of the following images:
- File:MOC_fibers_and_the_cholinergic_synapse_onto_OHCs_in_the_mature_Organ_of_Corti.jpg licensed with Cc-by-2.5, Cc-by-2.5
- 2009-02-12T23:15:32Z Mike.lifeguard 2076x525 (113339 Bytes) {{Information |Description={{en|1=Schematics Showing the Central Origin (A) and Peripheral Projections (B) of the MOC Fibers and the Cholinergic Synapse onto OHCs in the Mature Organ of Corti (C) MOC efferent neurons are loc
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This is a retouched picture, which means that it has been digitally altered from its original version. Modifications: Vectorized. The original can be viewed here: MOC fibers and the cholinergic synapse onto OHCs in the mature Organ of Corti-B.png: . Modifications made by Mike.lifeguard.
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I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution 2.5 Generic license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Original upload log edit
This image is a derivative work of the following images:
- File:MOC_fibers_and_the_cholinergic_synapse_onto_OHCs_in_the_mature_Organ_of_Corti-B.png licensed with Cc-by-2.5, Cc-by-2.5/en
- 2009-02-15T03:26:42Z Mike.lifeguard 688x515 (196919 Bytes) {{Information |Description={{en|1=Schematics Showing the Central Origin (A) and Peripheral Projections (B) of the MOC Fibers and the Cholinergic Synapse onto OHCs in the Mature Organ of Corti (C) MOC efferent neurons are loc
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current | 04:05, 15 February 2009 | 1,339 × 997 (5.23 MB) | Mike.lifeguard (talk | contribs) | {{Information |Description={{en|1=Schematics Showing the Central Origin (A) and Peripheral Projections (B) of the MOC Fibers and the Cholinergic Synapse onto OHCs in the Mature Organ of Corti (C) MOC efferent neurons are located in the superior olivary c |
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