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File:Metabolic pathways peroxinitrite DE.svg

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Deutsch: Entstehung von Peroxinitrit und dessen potenziellen Reaktionsmöglichkeiten im menschlichen Stoffwechsel. Peroxinitrit (ONOO–) bzw. Peroxisalpetersäure (ONOOH) können direkt mit verschiedenen Biomolekülen reagieren ((a) und (b)). Die Reaktion von Peroxinitrit mit Kohlenstoffdioxid (CO2) läuft besonders schnell ab und führt zur Entstehung von radikalischem Stickstoffdioxid (·NO2) und Carbonat-Radikalanionen (CO3·–) (c), die ihrerseits wiederum Proteine und DNS schädigen können (d). Peroxisalpetersäure, die leicht Zellmembranen passiert (e), kann in hydrophober Umgebung in Hydroxyl- (·OH) und Stickstoffdioxid-Radikale zerfallen (f) und dort Lipide und Proteine schädigen (g).

Csaba Szabó, Harry Ischiropoulos, Rafael Radi (2007). "Peroxynitrite: biochemistry, pathophysiology and development of therapeutics". Nature Reviews Drug Discovery 6: 662–680. DOI:10.1038/nrd2222.
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w:en:Creative Commons
attribution share alike
This file is licensed under the Creative Commons Attribution-Share Alike 3.0 Unported license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
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current15:29, 19 October 2010Thumbnail for version as of 15:29, 19 October 2010898 × 990 (52 KB)Sponk (talk | contribs)(recovering embedded text blocks while retaining most of Yikrazuul's changes)
17:01, 18 October 2010Thumbnail for version as of 17:01, 18 October 2010898 × 990 (190 KB)Yikrazuul (talk | contribs)Kleinkram (Rechtschreibung)
06:38, 26 September 2010Thumbnail for version as of 06:38, 26 September 2010898 × 990 (52 KB)Sponk (talk | contribs)== {{int:filedesc}} == {{Information |Description={{de|Entstehung von Peroxinitrit und dessen potenziellen Reaktionsmöglichkeiten im menschlichen Stoffwechsel. Peroxinitrit (ONOO<sup>–</sup>) bzw. Peroxisalpet

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