File:Neto1-Is-a-Novel-CUB-Domain-NMDA-Receptor–Interacting-Protein-Required-for-Synaptic-Plasticity-and-pbio.1000041.g013.jpg
Neto1-Is-a-Novel-CUB-Domain-NMDA-Receptor–Interacting-Protein-Required-for-Synaptic-Plasticity-and-pbio.1000041.g013.jpg (669 × 506 pixels, file size: 111 KB, MIME type: image/jpeg)
File information
Structured data
Captions
Summary edit
DescriptionNeto1-Is-a-Novel-CUB-Domain-NMDA-Receptor–Interacting-Protein-Required-for-Synaptic-Plasticity-and-pbio.1000041.g013.jpg |
English: (A) Latency to find the platform of wild-type and Neto1-null mice at each day of training in the Morris water maze task. Mice were administered either vehicle (25% cyclodextran) or 15 mg/kg CX546. During pretraining, escape latency to a visible-cued (V) platform located in the northeast (NE) quadrant was unaffected by genotype (unpublished data). In the acquisition phase (days 1–6), escape latency to find a hidden platform located in the southeast (SE) quadrant was also unaffected by genotype (F1,10 = 0.544, p > 0.05). In the second acquisition phase (days 7–9), Neto1-null mice treated with vehicle had longer escape latencies compared with Neto1-null mice treated with CX546, as well as wild-type mice treated with the vehicle control or CX546 when the hidden platform was relocated to the northwest (NW) quadrant (three-way ANOVA, genotype effect, F1,20 = 8.28, p < 0.01). In contrast, Neto1-null mice treated with CX546 had escape latencies identical to wild-type mice treated with the vehicle or CX546 (one-way ANOVA, F1,15 = 0.45; p = 0.7). There was no difference in escape latency between Neto1-null and wild-type mice treated with CX546 (F1,10 = 0.977, p > 0.05). |
|
Date | ||
Source | Image file from Ng D, Pitcher G, Szilard R, Sertié A, Kanisek M, Clapcote S, Lipina T, Kalia L, Joo D, McKerlie C, Cortez M, Roder J, Salter M, McInnes R (2009). "Neto1 Is a Novel CUB-Domain NMDA Receptor–Interacting Protein Required for Synaptic Plasticity and Learning". PLOS Biology. DOI:10.1371/journal.pbio.1000041. PMID 19243221. PMC: 2652390. | |
Author | Ng D, Pitcher G, Szilard R, Sertié A, Kanisek M, Clapcote S, Lipina T, Kalia L, Joo D, McKerlie C, Cortez M, Roder J, Salter M, McInnes R | |
Permission (Reusing this file) |
This file is licensed under the Creative Commons Attribution 3.0 Unported license.
|
|
Provenance InfoField |
|
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 19:34, 27 September 2014 | 669 × 506 (111 KB) | Recitation-bot (talk | contribs) | Automatic upload of media from: doi:10.1371/journal.pbio.1000041 |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.