File:Nwz043.pdf
Size of this JPG preview of this PDF file: 463 × 599 pixels. Other resolutions: 185 × 240 pixels | 371 × 480 pixels | 593 × 768 pixels | 1,275 × 1,650 pixels.
Original file (1,275 × 1,650 pixels, file size: 1.27 MB, MIME type: application/pdf, 26 pages)
File information
Structured data
Captions
Summary edit
DescriptionNwz043.pdf |
English: Brain size and cognitive skills are the most dramatically changed traits in humans during evolution, and yet the genetic mechanisms underlying these human-specific changes remain elusive. Here, we successfully generated 11 transgenic rhesus monkeys (8 first-generation and 3 second-generation) carrying human copies of MCPH1, an important gene for brain development and brain evolution. Brain image and tissue section analyses indicated an altered pattern of neural cell differentiation, resulting in a delayed neuronal maturation and neural fiber myelination of the transgenic monkeys, similar to the known evolutionary change of developmental delay (neoteny) in humans. Further brain transcriptome and tissue section analyses of major developmental stages showed a marked human-like expression delay of neuron-differentiation and synaptic signaling genes, providing a molecular explanation to the observed brain developmental delay of the transgenic monkeys. More importantly, the transgenic monkeys exhibited better short-term memory and shorter reaction time compared to the wild type controls in the delayed matching to sample task. The presented data represents the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model, and it values the use of nonhuman primates in understanding human unique traits. |
Date | |
Source |
https://academic.oup.com/nsr/advance-article/doi/10.1093/nsr/nwz043/5420749 https://doi.org/10.1093/nsr/nwz043 |
Author | Lei Shi, Xin Luo, Jin Jiang, Yongchang Chen, Cirong Liu, Ting Hu, Min Li, Qiang Lin, Yanjiao Li, Jun Huang, Hong Wang, Yuyu Niu, Yundi Shi, Martin Styner, Jianhong Wang, Yi Lu, Xuejin Sun, Hualin Yu, Weizhi Ji, Bing Su |
Licensing edit
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 11:30, 15 April 2019 | 1,275 × 1,650, 26 pages (1.27 MB) | Pamputt (talk | contribs) | User created page with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Short title | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development |
---|---|
Author | Shi, Lei |
Software used | Microsoft® Word 2010 |
Conversion program | 䵩捲潳潦璮⁗潲搠㈰㬠浯摩晩敤⁵獩湧呥硴卨慲瀠㐮ㄮ㘠批‱吳塔 |
Encrypted | no |
Page size | 612 x 792 pts (letter) |
Version of PDF format | 1.5 |