File:SORL1 schematic.png
Size of this preview: 530 × 599 pixels. Other resolutions: 212 × 240 pixels | 425 × 480 pixels | 1,000 × 1,130 pixels.
Original file (1,000 × 1,130 pixels, file size: 1.24 MB, MIME type: image/png)
File information
Structured data
Captions
Summary edit
DescriptionSORL1 schematic.png |
English: Schematic diagram of the multiple domains of SORLA, the protein product of the SORL1 gene. The relative orientations of the domains are drawn and color-coded to match the ectodomain model of Jensen et al., PNAS (2023). The N-terminal VPS10 domain is in green; the two 10CC domains are in red; The EGF domain is in orange; the 11 CR domains are in light cyan; the 6 3Fn domains are in light blue-grey. These 21 domains comprise the extracellular or ectodomain part of the protein, which in the eindosome is located inside the trafficking tubule. the ecotodomain is followed by a single-pass transmembrane alpha helix and a short (~54-residue) C-terminal tail (SORLA is a Type I integral membrane protein). The tail projects into the cytosol, where it interacts with the VPS26 subunit of retromer, the master controller of protein trafficking out of the early endosome. Cargo proteins and peptides can bind to the VPS10 domain or the CR domains, at least. Figure from Holstege et al., medRxiv (2023) https://www.medrxiv.org/content/10.1101/2023.07.13.23292622v1.full.pdf |
Date | |
Source | https://www.biorxiv.org/content/10.1101/2023.07.01.547348v2 |
Author | Olav Andersen |
Licensing edit
This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- share alike – If you remix, transform, or build upon the material, you must distribute your contributions under the same or compatible license as the original.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 16:04, 19 July 2023 | 1,000 × 1,130 (1.24 MB) | SimonCotter (talk | contribs) | Uploaded a work by Olav Andersen from https://www.biorxiv.org/content/10.1101/2023.07.01.547348v2 with UploadWizard |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
File usage on other wikis
The following other wikis use this file:
- Usage on en.wikipedia.org
Metadata
This file contains additional information such as Exif metadata which may have been added by the digital camera, scanner, or software program used to create or digitize it. If the file has been modified from its original state, some details such as the timestamp may not fully reflect those of the original file. The timestamp is only as accurate as the clock in the camera, and it may be completely wrong.
Compression scheme | Uncompressed |
---|---|
Pixel composition | RGB |
Image width | 1,000 px |
Color space | sRGB |
Image height | 1,130 px |