English: This is a “fly-into” sequences of the 3D structure of a typical plasma cell nucleus. The grey-levels have been inverted to aid visual 3D depth cues but this is brightfield imagery. Note the prominent peripheral clumps of chromatin without a central clump. The internal chromatin connections are relatively sparse and coarse compared to those of a hepatocyte (see movie 2). Also note the fine connections between peripheral clumps which are not obvious from an external inspection as the dominant features of the large clumps throughout the nucleus superimpose on an external view. Thus the ability to fly “into” the nucleus and look at these clumps from the inside out reveals morphological detail not otherwise easily appreciable and is one of the advantages of the methods presented in this study.