English: Example Trajectories Showing Important Residues in CDR2β Switch With SMX. SMX effects on the Vβ20-1 domain. Residues shown as sticks are labeled in the static image, Figure S6. Differences are observed in the initial structures between Movies S8 and S9. Overall, two amino acids, ASP 64 and LYS 65 effect a larger translated hydrogen bonding along the outer portions of the separate β loops, bridging between loops. The long range effects shown are seen to culminate in the constant loop region from β220-230, and also the position of the distal end of the CDR1-2β spanning loop. This shows how two single hydrogen bonds can be amplified and transmit a much larger signal across a protein from a ligand. SMX shown as wire model.