File:Summary of technical approaches to DNA screening.jpg
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From the study "Safety by design: Biosafety and biosecurity in the age of synthetic genomics"
Summary edit
| Description |
English: "Orders undergo 6-frame translation to retrieve protein sequences. Protein and nucleotide sequences are compared to publicly available protein and nucleotide sequences labeled with the taxonomic ID the sequence originates from, and best matches within the order are identified. Any best matches that correspond to regulated pathogens are flagged if they meet a minimum length requirement for screening (200 bases under 2010 US Government guidance but this threshold can differ from company to company). Sequences are also screened against a database of individual sequences of concern (e.g., controlled toxins). Hits to these sequences are also flagged. Flagged sequences undergo additional follow-up screening, where information available on the flagged sequence’s function is compared with the customer’s stated use case, publication history and institutional affiliation." |
| Date | |
| Source | https://www.cell.com/iscience/fulltext/S2589-0042(23)00242-0 |
| Author |
Authors of the study: Stefan A. Hoffmann James Diggans Douglas Densmore Junbiao Dai Tom Knight Emily Leproust Jef D. Boeke Nicole WheelerYizhi Cai |
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| current | 16:08, 3 April 2023 | | 3,333 × 1,103 (468 KB) | Prototyperspective (talk | contribs) | Uploaded a work by Authors of the study: Stefan A. Hoffmann James Diggans Douglas Densmore Junbiao Dai Tom Knight Emily Leproust Jef D. Boeke Nicole Wheeler Yizhi Cai from https://www.cell.com/iscience/fulltext/S2589-0042(23)00242-0 with UploadWizard |
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