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File:Type-I-Interferon-Programs-Innate-Myeloid-Dynamics-and-Gene-Expression-in-the-Virally-Infected-ppat.1003395.s003.ogv

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English: Temporal changes in innate myeloid cell dynamics during establishment of a persistent viral infection. Representative time lapses of 3D reconstructions show the dynamics of CX3CR1-GFP+/− labeled myeloid cells (green) captured by TPLSM through a thinned skull of mock or LCMV-infected OT-I CX3CR1-GFP+/− mice at the denoted time points. The maximal projections represent z-stacks (60 µm in depth) imaged over a 56 min time period. The blood vessels are labeled with quantum dots (red). Note the ramified microglia in mock-infected mice become highly activated by day 15. This is evidenced by their enlarged cell bodies and shortened processes. In addition, blood vessels are heavily patrolled by GFP+ cells at day 15. This response subsides over time.
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Source Movie S1 from Nayak D, Johnson K, Heydari S, Roth T, Zinselmeyer B, McGavern D (2013). "Type I Interferon Programs Innate Myeloid Dynamics and Gene Expression in the Virally Infected Nervous System". PLOS Pathogens. DOI:10.1371/journal.ppat.1003395. PMID 23737750. PMC: 3667771.
Author Nayak D, Johnson K, Heydari S, Roth T, Zinselmeyer B, McGavern D
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current01:49, 13 June 20133.8 s, 1,600 × 1,800 (16.23 MB)Open Access Media Importer Bot (talk | contribs)Automatically uploaded media file from Open Access source. Please report problems or suggestions here.

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