To image subcellular structures you need objectives with a high numerical aperture. But the resulting wide opening angle makes them especially susceptible to spherical aberrations caused by different refractive indices and interfaces in both the optical system and the sample. With Autocorr - a new generation of objectives - you simply adjust the optics of your microscope to your sample. Expect crisp contrast even deep inside in your specimen. And much more efficient fluorescence detection. You will get better data while less excitation intensity will improve the viability of your samples. www.zeiss.com/axioobserver