File:41541 2019 132 Fig2 HTML.webp
Size of this PNG preview of this WEBP file: 629 × 599 pixels. Other resolutions: 252 × 240 pixels | 504 × 480 pixels | 806 × 768 pixels | 1,075 × 1,024 pixels | 1,325 × 1,262 pixels.
Original file (1,325 × 1,262 pixels, file size: 153 KB, MIME type: image/webp)
File information
Structured data
Captions
Summary
editDescription41541 2019 132 Fig2 HTML.webp |
English: Hypothesised link between the innate immune response induced by vaccination and reactogenicity. Upon vaccination, inflammation is triggered by innate immune activation of pattern-recognition receptors (PRR) including Toll-like receptors (TLRs) that recognize and bind antigens (green circle in skeletal muscle) and potential immune enhancers (purple circle in skeletal muscle) present in the vaccine formulation. Resident immune cells, mast cells, monocytes and macrophages are activated within minutes of injection and release soluble factors (proinflammatory cytokines, chemokines, effectors of the complement cascade) and vasodilators, that allow cell recruitment from blood but also lead to the development of redness and swelling symptoms. These newly recruited immune cells, mainly composed of blood-born neutrophils, monocytes and T lymphocytes, also contribute to pain sensation by releasing soluble factors, such as cytokines, prostaglandins or ATP, that can directly interact with local sensory receptors called nociceptors and cause pain through the fast neural route if the threshold is reached. Once produced, cytokines act both locally in autocrine and paracrine manners, and may act systemically at distant organs, leading to the production of C-reactive protein and other acute phase proteins by the liver. Several immune-to-brain signaling pathways may propagate an inflammatory response to the central nervous system after peripheral activation of the innate immune system (slow humoral route), leading to the development of fever and sickness behaviours |
Date | |
Source | Hervé, C., Laupèze, B., Del Giudice, G. et al. The how’s and what’s of vaccine reactogenicity. npj Vaccines 4, 39 (2019). https://doi.org/10.1038/s41541-019-0132-6 |
Author | Caroline Hervé, Béatrice Laupèze, Giuseppe Del Giudice, Arnaud M. Didierlaurent, and Fernanda Tavares Da Silva |
Licensing
editThis file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 10:33, 6 October 2021 | 1,325 × 1,262 (153 KB) | Guest2625 (talk | contribs) | Uploaded a work by Caroline Hervé, Béatrice Laupèze, Giuseppe Del Giudice, Arnaud M. Didierlaurent, and Fernanda Tavares Da Silva from Hervé, C., Laupèze, B., Del Giudice, G. et al. The how’s and what’s of vaccine reactogenicity. npj Vaccines 4, 39 (2019). https://doi.org/10.1038/s41541-019-0132-6 with UploadWizard |
You cannot overwrite this file.
File usage on Commons
The following page uses this file:
File usage on other wikis
The following other wikis use this file:
- Usage on en.wikipedia.org