File:41541 2020 159 Fig2 HTML.webp
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editDescription41541 2020 159 Fig2 HTML.webp |
English: Critical quality attributes (CQAs) that dictate the performance of the mRNA construct to express the gene of interest efficiently. Five principal CQAs include 5′ capping efficiency and structure; UTR structure, length, and regulatory elements; modification of coding sequence; poly-A-tail properties; mRNA purity. |
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Source | Jackson, N.A.C., Kester, K.E., Casimiro, D. et al. The promise of mRNA vaccines: a biotech and industrial perspective. npj Vaccines 5, 11 (2020). https://doi.org/10.1038/s41541-020-0159-8 |
Author | Nicholas A. C. Jackson, Kent E. Kester, Danilo Casimiro, Sanjay Gurunathan, and Frank DeRosa |
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