In many parts of South Africa Aloe arborescens is planted around kraals (domestic stock enclosures) as a living fence. It often happens that the position of old kraals can still be seen many years after they have been abandoned because the aloes persist. Cuttings intended for use as barrier plants are sold in muthi shops.

The Zulu people use the leaves of this plant, dried and pounded into a powder, as a protection against storms. Decoctions of the leaves are also used in childbirth and in treating sick calves. In the Transkei it is used for stomach ache and given to chickens to prevent them from getting sick. In the Orient, this aloe is grown in domestic gardens as a convenient first-aid treatment for burn wounds and abrasions. In fact it was only after it was used to treat irradiation burn victims of Hiroshima that its healing properties received attention from the West. Extracts from the leaves have been widely investigated since then and shown significant wound healing, anti-bacterial, anti-ulcer, anti-inflammatory, anti-carcinogenic, hypoglycaemic and also alopoeic activity. The leaves have also been found to have purgative properties and the leaf sap is reported to relieve x-ray burns.