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| Description | Figure 1. An overview of epithelial–mesenchymal plasticity causes and consequences. Multiple signaling pathways such as TGF-𝛽, HIF-1𝛼 and Notch have been implicated in driving epithelial–mesenchymal transition (EMT). All these pathways tend to converge to a core regulatory circuit which includes two EMT-inducing transcription factors (EMT-TFs), SNAIL and ZEB, and two microRNAs, miR-34 and miR-200. The core regulatory circuit exhibits multi-stable dynamics: multiple stable steady states for the same level of EMT-inducing signal. These stable steady states contain different levels of SNAIL/ZEB/miR-34/miR-200 and thus corresponding to different EMT-associated phenotypes. The multi-stable dynamics of the core regulatory circuit allow for transitions among different stable states which leads to epithelial–mesenchymal plasticity. Cancer epithelial–mesenchymal plasticity typically enhances metastasis, allowing for disparate forms of migration and dissemination. In addition, epithelial–mesenchymal plasticity has been implicated in the acquisition of stem cell-like properties and immune evasion. |
| Date | |
| Source | https://www.mdpi.com/2077-0383/8/5/725 Quantifying Cancer Epithelial-Mesenchymal Plasticity and its Association with Stemness and Immune Response. J. Clin. Med. 2019, 8, 725. https://doi.org/10.3390/jcm8050725 |
| Author | Jia, D.; Li, X.; Bocci, F.; Tripathi, S.; Deng, Y.; Jolly, M.K.; Onuchic, J.N.; Levine, H. |
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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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| current | 22:42, 29 May 2024 | | 2,790 × 2,059 (913 KB) | Rasbak (talk | contribs) | {{Information |description= Figure 1. An overview of epithelial–mesenchymal plasticity causes and consequences. Multiple signaling pathways such as TGF-𝛽, HIF-1𝛼 and Notch have been implicated in driving epithelial–mesenchymal transition (EMT). All these pathways tend to converge to a core regulatory circuit which includes two EMT-inducing transcription factors (EMT-TFs), SNAIL and ZEB, and two microRNAs, miR-34 and miR-200. The core regulatory circuit exhibits multi-stable dynamics: multiple... |
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