English: Atorvastatin synthesis during discovery chemistry. The key step establishing a stereocenter in the apparent first enantioselective route to atorvastatin, making use of a chiral ester auxiliary to set the stereochemistry of the first alcohol functional group via a diastereoselective aldol reaction. Associated REF B.D. Roth , C.J. Blankley , A.W. Chucholowski , E. Ferguson , M.L. Hoefle , D.F. Ortwine , R.S. Newton , C.S. Sekerke , D.R. Sliskovic , M. Wilson (1991). "Inhibitors of Cholesterol Biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one Inhibitors of HMG-CoA Reductase. 2. Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus". J. Med. Chem. 34: 357–366. DOI:10.1021/jm00105a056.. Created by dividing/cropping original image File:Atorvastatin_routes.png of User:Jammercer. NOTE: Integrity of information contained in the image is judged reasonable by this expert, but this citation was not actually contained in the source file, and image details were not checked against this inferred source. Use source and image only with verification of content for each intended purpose. Le Prof