File:Barriera intestinale.jpg
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Italiano: Sistema di barriera intestinale in condizioni dietetiche normali. Allo stato stazionario, il tratto intestinale utilizza varie strategie per prevenire la traslocazione di materiale estraneo dal lume nella lamina propria (LP). Il muco derivato dalle cellule caliciformi previene la violazione batterica del monostrato di enterociti formando una barriera fisica, migliorando la degradazione tramite le defensine e stimolando le risposte immunitarie regolate attraverso le IgA secrete. Inoltre, il LP viene mantenuto in uno stato antinfiammatorio per la presenza di cellule dendritiche antinfiammatorie e citochine associate. Infine, le giunzioni strette (TJ) formate tra gli enterociti sono numerose e consentono selettivamente la permeazione delle molecole mentre contemporaneamente murano l'LP dal lume. Ci sono molte proteine coinvolte nel mantenimento della TJ. tra cui occludin, claudine, caderine, ecc. e queste proteine sono parte integrante del mantenimento della barriera intestinale. IEC, cellula epiteliale intestinale. |
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| Source | Michael W Rohr, Chandrakala A Narasimhulu, Trina A Rudeski-Rohr, Sampath Parthasarathy, Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review, Advances in Nutrition, Volume 11, Issue 1, January 2020, Pages 77–91, https://doi.org/10.1093/advances/nmz061 |
| Author | Michael W Rohr, Chandrakala A Narasimhulu, Trina A Rudeski-Rohr, Sampath Parthasarathy, |
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| current | 16:20, 19 December 2021 | | 1,606 × 857 (931 KB) | OppidumNissenae (talk | contribs) | Uploaded a work by Michael W Rohr, Chandrakala A Narasimhulu, Trina A Rudeski-Rohr, Sampath Parthasarathy, from Michael W Rohr, Chandrakala A Narasimhulu, Trina A Rudeski-Rohr, Sampath Parthasarathy, Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review, Advances in Nutrition, Volume 11, Issue 1, January 2020, Pages 77–91, https://doi.org/10.1093/advances/nmz061 with UploadWizard |
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