File:Cannabioid agonist WIN acting on pancreatic stellate cell.png
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DescriptionCannabioid agonist WIN acting on pancreatic stellate cell.png |
English: Figure 8. Cannabinoid receptor activation reduces invasiveness.
A significant reduction in the number of invaded cells was seen after treatment with WIN (p = 0.0081; A). A near-complete reversal of the reduced invasiveness was seen when the cells were pre-incubated with AM251 or a combination of AM251 and AM630 (A). This was not found with AM630 alone (A). WIN induced a significant decrease in MMP-2 levels (p = 0.026; B) which was partially reversible by a combination of AM251 and AM630 (B). Actin cytoskeleton staining with phalloidin demonstrated that control PSC showed the normal cellular structure (C&D) but that WIN induced a more round and smaller PSC phenotype (E&F). Original magnification: x 40 (C&E), x 80 (D&F). Nuclear stain: DAPI. White bars: control; black bars: WIN55,212-2±AM251/AM630. Data are shown as mean±SEM. Русский: Агонист каннабиноидных рецепторов снижает характеристики воспаления в панкреатических звездчатых клетках. |
Date | |
Source | Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells |
Author | Christoph W. Michalski1,2#*, Milena Maier2#, Mert Erkan1#, Danguole Sauliunaite1, Frank Bergmann3, Pal Pacher4, Sandor Batkai4, Nathalia A. Giese2, Thomas Giese5, Helmut Friess1, Jörg Kleeff1 |
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current | 18:30, 28 August 2009 | 2,000 × 2,516 (1.85 MB) | CopperKettle (talk | contribs) | downsize | |
18:28, 28 August 2009 | 4,134 × 5,201 (2.78 MB) | CopperKettle (talk | contribs) | {{Information |Description={{en|1=Figure 5. AM251 induces changes in PSC phenotype. (A) Invasion assays demonstrated a trend toward increased invasiveness induced by AM251. (B) MMP-2 levels were unchanged by antagonist treatment. (C&D) AM251-treated panc |
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