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File:Catalytic mechanisms of Topoisomerases.gif

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Illustration showing the Catalytic mechanisms of Topoisomerases

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Description
English: Summary of topoisomerase types and catalytic mechanisms. The topoisomerases are categorised based on whether they catalyse single- (type I) or double-stranded (type II) DNA breaks. The type I topoisomerases are further subdivided to type IA, IB and IC. Type IA form a transient covalent bond to the 5ʹ DNA phosphate and function via a strand passage mechanism. Type IB and IC form a transient covalent bond to the 3ʹ DNA phosphate and function via a controlled-rotation mechanism. Type II topoisomerases are further subdivided into type IIA and IIB. Both form a transient covalent bond to the 5ʹ DNA phosphate of both strands of the duplex and function via a strand-passage mechanism
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Author Kcneuman

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current06:11, 10 April 2022Thumbnail for version as of 06:11, 10 April 20221,841 × 444 (43 KB)Kcneuman (talk | contribs)Uploaded own work with UploadWizard

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