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File:Cellular Prevalence of Mutations.png

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Clonal evolution model

Summary

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Description
English: (a) A hypothetical phylogenetic tree generated by clonal expansion via the accumulation of mutations (stars). Unlike traditional phylogenetic trees internal nodes (clones) in the tree may contribute to the observed data, not just the leaf nodes. (b) Hypothetical observed cellular prevalences for the mutations in tree. Mutations occurring higher up the tree always have a greater cellular prevalence than their descendants (the same statement need not be true about variant allelic prevalence because of the effect of genotype). Note that the green, blue and purple mutations occur at the same cellular prevalence because they always co-occur in the clones of the tree.
Date
Source https://media.nature.com/original/nature-assets/nmeth/journal/v11/n4/extref/nmeth.2883-S1.pdf
Author Andrew Roth, Jaswinder Khattra, Damian Yap, Adrian Wan, Emma Laks, Justina Biele, Gavin Ha, Samuel Aparicio, Alexandre Bouchard-Côté & Sohrab P Shah

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