File:Cellular adhesion on submicron topographies controls EMTMET.jpg
Original file (916 × 1,840 pixels, file size: 891 KB, MIME type: image/jpeg)
Captions
Captions
Summary
edit
| Description | Figure 6. Cellular adhesion on submicron topographies controls EMT/MET. a Primary human corneal epithelial cells ordinarily adopt compact, rounded morphologies. b Adhesion to grooved topographies with submicron spacing biases focal adhesions along grooves. c Epithelial cells subsequently orient and elongate along the groove direction, analogous to an EMT. d Monolayers of canine kidney epithelial cells (MDCK) migrate as multicellular strands (partial EMT) and individuals (complete EMT) on submicron grooved topographies. e Crosstalk of YAP and E-cadherin via WT1 regulates partial and complete EMT states. f, g Mesenchymal breast cancer cell lines on smooth gold surfaces exhibited elongated morphologies with minimal cytokeratin (red) and strong vimentin (green) expression. h, i. Mesenchymal breast cancer cell lines on textured gold surfaces exhibited compact, clustered morphologies with strong cytokeratin (red) and weak vimentin (green) expression, indicative of a mesenchymal-to-epithelial transition. |
| Date | |
| Source | https://biosignaling.biomedcentral.com/articles/10.1186/s12964-021-00713-2#rightslink The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems. Cell Commun Signal 19, 32 (2021). https://doi.org/10.1186/s12964-021-00713-2 |
| Author | Leggett, S.E., Hruska, A.M., Guo, M. et al. |
|
This file, which was originally posted to an external website, has not yet been reviewed by an administrator or reviewer to confirm that the above license is valid. See Category:License review needed for further instructions.
|
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Licensing
edit
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 21:19, 16 May 2024 | | 916 × 1,840 (891 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 6. Cellular adhesion on submicron topographies controls EMT/MET. a Primary human corneal epithelial cells ordinarily adopt compact, rounded morphologies. b Adhesion to grooved topographies with submicron spacing biases focal adhesions along grooves. c Epithelial cells subsequently orient and elongate along the groove direction, analogous to an EMT. d Monolayers of canine kidney epithelial cells (MDCK) migrate as multicellular strands (partial EMT) and individ... |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.
