File:Cochlea defects in mutants.png
Size of this preview: 500 × 600 pixels. Other resolutions: 200 × 240 pixels | 400 × 480 pixels | 640 × 768 pixels | 853 × 1,024 pixels | 2,196 × 2,635 pixels.
Original file (2,196 × 2,635 pixels, file size: 7.42 MB, MIME type: image/png)
File information
Structured data
Captions
Summary edit
DescriptionCochlea defects in mutants.png |
English: (A–L) Confocal images (100×) of the surface of cochlear whole mounts isolated at E18.5 from <i\>LtapLp</i\>/+ (A,E,I), <i\>Dvl3</i\><sup\>−/−</sup\> (B, F,J), <i\>Dvl3</i\><sup\>+/−</sup\>;<i\>LtapLp</i\>/+ (C,G,K), <i\>Dvl3</i\><sup\>−/−</sup\>;<i\>LtapLp</i\>/+ (D,H,L). Images show comparable regions in each mouse at the base (A–D), middle (E–H) and apex (I–L) of the cochlear ducts. In A–L brackets and arrowheads indicate the outer and inner hair cells, respectively. In A–H white stars indicate misoriented stereociliary bundles and in I–L dotted circles in the left panels outline regions presented in the right panels. (M–P) Light micrographs of the inner ears (top) and isolated cochlea ducts (bottom) isolated at E18.5 from <i\>LtapLp</i\>/+ (M), <i\>Dvl3</i\><sup\>−/−</sup\> (N), <i\>Dvl3</i\><sup\>+/−</sup\>;<i\>LtapLp</i\>/+ (O), <i\>Dvl3</i\><sup\>−/−</sup\>;<i\>LtapLp</i\>/+ (P) samples. The yellow dotted line traces each cochlear spiral and the brackets indicate the cochlea portion of the inner ear. (Q–S) Confocal images (40×) of the surface of cochlear whole mounts isolated at E18.5 from <i\>LtapLp</i\>/+ (Q), <i\>Dvl3</i\><sup\>+/−</sup\>;<i\>LtapLp</i\>/+ (R), <i\>Dvl3</i\><sup\>−/−</sup\>;<i\>LtapLp</i\>/+ (S) mutants. Images show comparable regions in each cochlea. (T) Expression of Dvl3-EYFP transgene (green) and stereocilary bundles (red) in the vestibular utricle region of the inner ear. White stars indicate cells in which the asymmetric localization of Dvl3 is very clear. (U) Expression of Dvl3-EYFP transgene in the cochlear duct. Arrows indicate the polarized localization of Dvl3, towards the lateral side of the sensory hair cells. |
Date | |
Source | Murine Dishevelled 3 Functions in Redundant Pathways with Dishevelled 1 and 2 in Normal Cardiac Outflow Tract, Cochlea, and Neural Tube Development ([1]) |
Author | S. Leah Etheridge, Saugata Ray, Shuangding Li, Natasha S. Hamblet, Nardos Lijam, Michael Tsang, Joy Greer, Natalie Kardos, Jianbo Wang, Daniel J. Sussman, Ping Chen, Anthony Wynshaw-Boris |
Licensing edit
This file is licensed under the Creative Commons Attribution 2.5 Generic license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 04:43, 12 February 2009 | 2,196 × 2,635 (7.42 MB) | Mike.lifeguard (talk | contribs) | {{Information |Description={{en|1=(A–L) Confocal images (100×) of the surface of cochlear whole mounts isolated at E18.5 from <i\>LtapLp</i\>/+ (A,E,I), <i\>Dvl3</i\><sup\>−/−</sup\> (B, F,J), <i\>Dvl3</i\><sup\>+/−</sup\>;<i\>LtapLp</i\>/+ (C,G, |
You cannot overwrite this file.
File usage on Commons
There are no pages that use this file.