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File:Consumption of a Damaged 2′-Deoxynucleoside Contributes to DNA Damage in the Small Intestines of Rodents.jpg

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From the study "Possible Genetic Risks from Heat-Damaged DNA in Food"

Summary

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Description
English: "Adverse genetic effects of feeding high levels of a damaged nucleoside to mice. (a) Schematic illustration of oral feeding of dU to mice and analysis of intestinal tissue. LC–MS/MS quantification results of (b) dU and (c) 8-oxo-dG in gDNA extracted from the intestines of control (−) and dU-fed mice (+), showing 2.5-fold to 15-fold increases in levels of dU in the genomic DNA from these tissues. (d) Immunostaining of γ-H2AX in villi in the small intestine, showing enhanced DNA double-strand break (DSB) signals in response to dU feeding. Also shown are images of crypts in the large intestine. Tissues were costained with Hoechst 33343 (5 μg/mL) to highlight nuclear DNA. (e) Quantified intensities of γ-H2AX from red channels in panel d. Uncertainties are standard deviations (****p ≤ 0.0001) by the unpaired t test."
Date
Source https://pubs.acs.org/doi/10.1021/acscentsci.2c01247
Author Authors of the study: Yong Woong Jun, Melis Kant, Erdem Coskun, Takamitsu A. Kato, Pawel Jaruga, Elizabeth Palafox, Miral Dizdaroglu, and Eric T. Kool

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