File:EMTMET intermediates. (A–E) Intermediate cells hybrid partial EMT cells.jpg
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| Description | Figure 3 EMT/MET intermediates. (A–E) Intermediate cells: hybrid/partial EMT (pEMT) cells. nth: The transition phase indicates the number of transitions that may occur before M cells are formed, which is indeterminate but could be dictated by many factors including the tumour microenvironmental cues. Intermediate cells possess dynamic characteristics that are central to increased metastatic potential. Hybrid/pEMT “C”: indicates an unspecific hypothetical stage. The time taken (known as first arrival time (FAT) distribution) for E or M cells to transition to each other, or individual pMET/hybrid cell at the nth phase varies depending on (i) epigenetic changes (histone modification or methylation), (ii) presence of anti-EMT/pro-MET factors (such as OVOL 1/2, GRHL-2, ESRP-1/2, and various microRNAs (including miR20 family), among others. Generally, the stability of hybrid E/M is controlled by some factors known as phenotypic stability factors (PSFs) and their metabolic, genomic, and morphologic states. However, as these intermediate cells possess some similar characteristics, they also have different phenotypic behaviours. They possess identical properties such as tumour-initiating potential but are also significantly contrastive, based on (i) cellular plasticity, (ii) degree of invasiveness, and (iii) metastatic potential. Among all the intermediate phenotypes, however, intermediate M possesses the highest migratory potential, the highest degree of invasiveness, most primed to form spindle-shaped phenotype and the highest resistance to anoikis. |
| Date | |
| Source | https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.762817/full Understanding the Complex Milieu of Epithelial-Mesenchymal Transition in Cancer Metastasis: New Insight Into the Roles of Transcription Factors. Front. Oncol. 11:762817. doi: 10.3389/fonc.2021.762817 |
| Author | Imodoye SO, Adedokun KA, Muhammed AO, Bello IO, Muhibi MA, Oduola T and Oyenike MA |
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Copyright © 2021 Imodoye, Adedokun, Muhammed, Bello, Muhibi, Oduola and Oyenike. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 10:11, 19 May 2024 | | 4,222 × 2,718 (600 KB) | Rasbak (talk | contribs) | {{Information |description=Figure 3 EMT/MET intermediates. (A–E) Intermediate cells: hybrid/partial EMT (pEMT) cells. nth: The transition phase indicates the number of transitions that may occur before M cells are formed, which is indeterminate but could be dictated by many factors including the tumour microenvironmental cues. Intermediate cells possess dynamic characteristics that are central to increased metastatic potential. Hybrid/pEMT “C”: indicates an unspecific hypothetical stage. The... |
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