File:Early pre- and post-implantation mouse embryonic development until the egg cylinder stage.png
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FIGURE 1. Early pre- and post-implantation mouse embryonic development until the egg cylinder stage. (A) Following fertilization, the embryo undergoes a series of cleavage divisions as it travels down the fallopian tube. Between 3.5 and 4.5 dpc, the embryo, now known as a blastocyst, consists of two cell populations: An outer multipotent trophectoderm (TE) (expressing Cdx2), and a mosaic inner pluripotent inner cell mass (ICM) population. At 4.0 dpc, the blastocyst hatches from the zona pelucida and implants into the uterine wall. (B) Cells of the 4.0 dpc ICM expressing Gata6 and Sox17 move to line the blastocoelic cavity, lose pluripotency, and differentiate into the extraembryonic primitive endoderm (or hypoblast) by 4.5 dpc. Together the remaining cells of the ICM (the epiblast) and the hypoblast form the bilaminar disc by 5.0 dpc. At this stage, cells of the pluripotent epiblast that have not moved to be in contact with the extracellular matrix laid down between the hypoblast undergo apoptosis to help form the proamniotic cavity. Hypoblast cells that remain in close contact with the epiblast differentiate into visceral endoderm (VE) while those that migrate along the basement membrane of the TE form the tPA+ parietal endoderm (PaE), resulting in the formation of the yolk sac. At 5.5 dpc the embryo is known as the egg cylinder. The remaining surviving epiblast cells have differentiated into a second pluripotent population of pseudo-stratified cells known as the primitive ectoderm (PrEct). The TE differentiates into cells that constitute the placenta including the extraembryonic endoderm (EXE). |
| Date | |
| Source | https://www.researchgate.net/publication/334407321_Modeling_Mammalian_Commitment_to_the_Neural_Lineage_Using_Embryos_and_Embryonic_Stem_Cells Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells. July 2019. Frontiers in Physiology 10 DOI:10.3389/fphys.2019.00705 |
| Author | Rachel A. Shparberg, Hannah J. Glover, Michael B. Morris |
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Copyright © 2019 Shparberg, Glover and Morris. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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| current | 09:53, 30 April 2024 | | 1,089 × 1,228 (613 KB) | Rasbak (talk | contribs) | {{Information |description=FIGURE 1. Early pre- and post-implantation mouse embryonic development until the egg cylinder stage. (A) Following fertilization, the embryo undergoes a series of cleavage divisions as it travels down the fallopian tube. Between 3.5 and 4.5 dpc, the embryo, now known as a blastocyst, consists of two cell populations: An outer multipotent trophectoderm (TE) (expressing Cdx2), and a mosaic inner pluripotent inner cell mass (ICM) population. At 4.0 dpc, the blastocyst... |
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