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English: During differentiation a myriad of adipogenic loci are under the influence of chromatin modifying complexes. This figure outlines 2 major points of regulation of adipogenesis. b) PPARγ target regulation. PPARγ acts on a variety of genes implicated in adipocyte differentiation and function. Rb, a factor that binds PPARγ, is known to have a negative effect on PPARγ action in adipogenesis. This is due to its binding deacetylases in its unphosphorylated form that then act on PPARγ's target promoters. In the event that Rb is phosphorylated PPARγ binds acetyltransferases, which then acetylate histones at PPARγ target promoters, allowing transcription to occur.
Date Published March 31, 2009.
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StemBook Figure 3 (Continued) Epigenetics of adipose development.

  • Cook, A. and Cowan, C., Adipose (March 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.40.1, http://www.stembook.org.
Author Cook, A. and Cowan, C., Adipose (March 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.40.1, http://www.stembook.org.
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