File:Esquema de los tres tipos de PKSs.png
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editDescriptionEsquema de los tres tipos de PKSs.png |
Español: a) Las PKS de tipo I están formadas por polipéptidos multifuncionales. Cada subunidad contiene uno o más módulos que incorporan dominios catalíticos plegados individualmente. Cada módulo actúa una vez (no de forma iterativa) para extender la cadena y llevar a cabo reacciones de procesamiento reductivo. En cada módulo, se indican tanto el bloque de construcción agregado como la funcionalidad establecida por las actividades reductoras. b) Las PKS de tipo II constan de funciones catalíticas discretas que se asocian en un complejo productivo. La “PKS mínima” incluye los dominios KSα, KSβ y ACP, que iteran a través de un número definido de ciclos de extensión de cadena para construir una cadena de policetona. La estequiometría exacta del complejo KSα/KSβ/ACP aún está por determinar. c) Las PKS de tipo III consisten en un único sitio activo multifuncional que, en cooperación con sustratos unidos a CoA, realiza todos los pasos necesarios para ensamblar una cadena de policetona de longitud definida. |
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Author | Galnex |
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