Three of the 'Doddiscombsleigh workshop' panels of circa 1470, which were formerly in the Chapter House.

The original window was erected Circa 1300, as a six light window. When the east end of the cathedral was rebuilt, it had 3 lights added. Glazed first by Master Walter of Rouen in 1304 , it suffered a large amount of masonry decay by the 1380s and had to be remade. The new design, completed in 1390, involved carrying four central mullions to the head of the window, and adding strength by securing them with transoms. In 1391 Robert Lyen of Exeter was commissioned to glaze the new window, resetting the surviving early 14th century glass and adding new panels where needed.

After the Reformation the window suffered some damage, losing several figures in its lowest and middle tiers. In the 18th century two restorations saw the introduction into the window of late medieval glass from elsewhere in the cathedral. Between 1894 and 1896 Frederick Drake, completely restored the east window glass. Between 1982 and 1986 the glass was conserved by Chapel Studios.

At the top and bottom of the window there are many coats of arms. Continuing down in the middle is: Abraham, Moses, and Isaiah. The row beneath this depicts Saint Sidwell (a female Saint of Devon), St Helen, an Archangel, St Michael, St Catherine, St Edward the Confessor, and St Edmund. The main figures of the window are: St Margaret, St Catherine, Mary Magdalene, St Barbara, The Virgin and Child, St Martin, St Peter, St Paul, and St Andrew.