File:Faulty molecular master switch may contribute to AMD (46820119492).jpg
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In healthy retina (left), microglia (green) demonstrate a branched structure that covers the retina. Without TGFβ signaling (right), microglia lose their branched structure, and attach to blood vessels (white). Müller glia become abnormal and acquire activation markers (red). A signaling pathway controlled by transforming growth factor beta (TGFβ) could be involved in the progression of age-related macular degeneration (AMD). Researchers at the National Eye Institute (NEI), part of the National Institutes of Health, have found that interrupting TGFβ signals to immune cells called microglia causes the cells to enter an activated, inflammatory state. These activated microglia damage the retina, the light-sensitive tissue at the back of the eye. This damage is similar to cellular effects observed in AMD, a common cause of vision loss among older Americans. Read more: <a href="https://www.nih.gov/news-events/news-releases/faulty-molecular-master-switch-may-contribute-amd" rel="noreferrer nofollow">www.nih.gov/news-events/news-releases/faulty-molecular-ma...</a> Credit: Wenxin Ma, M.D., Ph.D., and Wai Wong, M.D., Ph.D., National Eye Institute/NIH |
| Date | |
| Source | Faulty molecular master switch may contribute to AMD |
| Author | NIH Image Gallery from Bethesda, Maryland, USA |
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This image is a work of the National Institutes of Health, part of the United States Department of Health and Human Services, taken or made as part of an employee's official duties. As a work of the U.S. federal government, the image is in the public domain.
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| This file has been identified as being free of known restrictions under copyright law, including all related and neighboring rights. | ||
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This image was originally posted to Flickr by National Institutes of Health (NIH) at https://flickr.com/photos/132318516@N08/46820119492. It was reviewed on 14 March 2020 by FlickreviewR 2 and was confirmed to be licensed under the terms of the Public Domain Mark. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 04:40, 12 March 2020 | | 900 × 900 (1.06 MB) | Ser Amantio di Nicolao (talk | contribs) | Transferred from Flickr via #flickr2commons |
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