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Deutsch: Vereinfachte schematische Darstellung des angenommenen Wirkungsmechanismus von FcRn-Inhibitoren (Abdeg, antibody that enhances IgG degradation) modifiziert nach D.D. Patel, J.B. Bussel: Neonatal Fc receptor in human immunity: Function and role in therapeutic intervention. In: Journal of Allergy and Clinical Immunology. Band 146, Nr. 3, 2020, S. 467–478, doi:10.1016/j.jaci.2020.07.015.
Links: IgG-Moleküle gelangen durch Pinozytose in die Zellen (1) und werden in Endosomen, die neonatale Fc-Rezeptoren (FcRn) enthalten, aufgenommen (2). Aufgrund des sauren pH-Werts in den Endosomen bindet der FcRn fest an den Fc-Teil von IgG. Es folgt eine Sortierung (3): Ungebundenes, überschüssiges IgG gelangt in Lysosomen (4) und wird dort abgebaut. Gebundene IgG-Moleküle werden zurückgehalten (5) und durch Exozytose (6) aus der Zelle heraus befördert. Im physiologischen (nahezu neutralen) pH-Wert des Blutes setzt der FcRn das IgG frei (7). Rechts: FcRn-Inhibitoren binden sowohl bei physiologischem als auch bei saurem pH-Wert mit größerer Affinität an den FcRn als endogenes IgG. Sie konkurrieren somit mit endogenem IgG um die FcRn-Bindung. Infolgedessen werden mehr endogene IgG-Moleküle dem lysosomalen Abbau zugeführt und weniger recycelt.
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current12:20, 19 January 2023Thumbnail for version as of 12:20, 19 January 20231,140 × 532 (109 KB)Polarlys (talk | contribs)text as text for further translation
00:09, 23 March 2022Thumbnail for version as of 00:09, 23 March 20221,140 × 532 (129 KB)Benff (talk | contribs)Uploaded own work with UploadWizard

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