File:Fmolb-04-00007-g002 (1).jpg

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Captions

Pelizaeus–Merzbacher disease

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Description
English: FIGURE 2. A SCHEMATIC PICTURE OF UNFOLDED PROTEIN RESPONSE AND ER CHAPERONES. GRP78 binding to unfolded proteins accumulated in ER results in dissociation from and activation of ER stress sensors, ATF6, PERK, and IRE1 (Szegezdi et al., 2006). Downstream signaling molecules function either to maintain cellular homeostasis or promote apoptosis. UPR result in increase of ER chaperones (CRT, CNX, GRP78, and PDI are depicted here) to enhance the protein folding capacity.
Date
Source https://www.frontiersin.org/articles/10.3389/fmolb.2017.00007/full
Author Ken Inoue

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current22:00, 4 April 2024Thumbnail for version as of 22:00, 4 April 2024460 × 415 (171 KB)Ozzie10aaaa (talk | contribs)Uploaded a work by Ken Inoue from https://www.frontiersin.org/articles/10.3389/fmolb.2017.00007/full with UploadWizard

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