File:Gynecomastia incidence during bicalutamide or spironolactone therapy as a function of dosage in men.png

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Description	English: Rates of gynecomastia during treatment with bicalutamide or spironolactone as a function of dosage in men. This graph was created based on the following data: A dose-ranging study found that gynecomastia occurred with bicalutamide in 9% at 10 mg/day, 26% at 30 mg/day, 36% at 50 mg/day, 79% at 100 mg/day, 78% at 150 mg/day, and 79% at 200 mg/day. Various studies have reported that spironolactone produces rates of gynecomastia of 5 to 10% at 25 to 50 mg/day, 17 to 30% at 75 to 100 mg/day, and 52 to 62% at 150 to 300 mg/day. Source of the values for bicalutamide: (1998). "Casodex 10-200 mg daily, used as monotherapy for the treatment of patients with advanced prostate cancer. An overview of the efficacy, tolerability and pharmacokinetics from three phase II dose-ranging studies. Casodex Study Group". Eur. Urol. 33 (1): 39–53. DOI:10.1159/000019526. PMID 9471040. Sources of the values for spironolactone: (October 1987). "Efficacy and tolerance of spironolactone in essential hypertension". Am. J. Cardiol. 60 (10): 820–5. DOI:10.1016/0002-9149(87)91030-7. PMID 3661395. (October 1978). "Gynecomastia induced in normal males by spironolactone". Clin. Pharmacol. Ther. 24 (4): 465–73. DOI:10.1002/cpt1978244465. PMID 688736. (15 August 2016) Interventional Therapies for Secondary and Essential Hypertension, Springer, pp. 44– ISBN: 978-3-319-34141-5.
Date	7 August 2018
Source	Own work
Author	Medgirl131

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