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Description
English: General mechanisms by which hemoglobinopathies may attenuate the pathogenesis of falciparum malaria.
  • (A) Restriction of red blood cell (RBC) invasion or intraerythrocytic growth, thereby suppressing parasite densities in vivo;
  • (B) interference with parasite-derived mediators of pathogenesis, including those involved in the binding of parasite-infected RBCs (iRBCs) to extracellular host receptors;
  • (C) modulation of innate host defenses to favor protective, anti-inflammatory responses over those that drive pathogenic, pro-inflammatory responses;
  • (D) enhancement of adaptive cell-mediated and humoral immune responses that clear iRBCs from the blood.
Date
Source Taylor SM, Cerami C, Fairhurst RM (2013) Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis. PLoS Pathog 9(5): e1003327. doi:10.1371/journal.ppat.1003327
Author Taylor SM, Cerami C, Fairhurst RM (2013)

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