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File:Hepatic induction..jpg

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English: The figure depicts the lateral view of the anterior portion of an e8.25 (2–4 somite stage) mouse embryo (right). The developing head is shown in grey. At this stage the definitive endoderm (yellow) is forming a foregut pocket. The liver (lv) is induced a portion of the ventral foregut by FGF signals from the cardiogenic mesoderm (red) and BMPs from the septum transversum mesenchyme (orange). Foregut endoderm isolated after the 5–7 somite stage will express liver genes such as Albumin, indicating that hepatic fate is specified. Different doses of FGF appear to induce lung (lu) and ventral pancreas (pa) from the foregut progenitors. Signals from the axial mesoderm (candidates included FGF4 and Wnt ligands) repress hepatic fate in the dorsal endoderm.
Date Published October 31, 2008.
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StemBook Figure 5 Hepatic induction.

  • Zorn, A.M., Liver development (October 31, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.25.1, http://www.stembook.org.
Author Zorn, A.M., Liver development (October 31, 2008), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.25.1, http://www.stembook.org.
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current18:54, 5 April 2013Thumbnail for version as of 18:54, 5 April 2013400 × 297 (37 KB)Smallbot (talk | contribs)Uploading CC-BY images from the the StemBook http://www.stembook.org/ 95/173

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