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File:Histone methyltransferases and demethylases function antagonistically to control gene expression pat.jpg

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English: Histone methyltransferases and demethylases function antagonistically to control gene expression patterns during ES cell differentiation. In pluripotent cells, the essential pluripotency gene Oct4 is maintained in an active state by the histone H3 K9 demethylases Jmjd1a and Jmjdc2 whose expression is in turn regulated by Oct4 to maintain self-renewal. Upon differentiation, G9a tri-methylates histone H3 lysine 9 in the promoter region of Oct4 which results in recruitment of HP1 and DNA methyltransferases, leading to stable gene repression and exit from pluripotency.
Date Published May 31, 2009.
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StemBook Figure 3 Histone methyltransferases and demethylases function antagonistically to control gene expression pat

  • Sha, K. and Boyer, L. A. The chromatin signature of pluripotent cells (May 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.45.1, http://www.stembook.org.
Author Sha, K. and Boyer, L. A. The chromatin signature of pluripotent cells (May 31, 2009), StemBook, ed. The Stem Cell Research Community, StemBook, doi/10.3824/stembook.1.45.1, http://www.stembook.org.
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