\documentclass[12pt,border=5pt,tikz,class=scrartcl,multi=false]{standalone}
\usepackage{times}
\usepackage[T1]{fontenc}
\usepackage[latin1]{inputenc}
\usepackage{mathtools,amssymb,siunitx}
\usepackage{pgfplots}
\pgfplotsset{compat=1.13}
\usepackage{gensymb}

\usepackage{chemfig,chemmacros}
\renewcommand*{\familydefault}{\sfdefault}
\renewcommand*\printatom[1]{\ensuremath{\mathsf{#1} } }
\setatomsep{1.5em}
\setdoublesep{.6ex}
\setarrowdefault{,1,ultra thick}
\setbondstyle{very thick,cap=round}
\definesubmol\nobond{-[,0.2,,,draw=none]}

\pagestyle{empty}
\thispagestyle{empty}
\begin{document}
\schemedebug{false}
\schemestart[][west]
	\chemfig{
		*6((-HO)-=(-N(-[0]H)-[6]ts)-=-=)
	}
	\arrow{->[*{0}\mbox{\color{blue}1]}]}[-90,,blue]
	\chemfig[blue]{
		*6((-HO)=-(-[:-30]N(-[6]ts)-[:30]-[::60]-[::60](=[2]O)-[::50,0.7]H)=-=-)
	}
	\arrow{->}[-90,,blue]
	\chemfig[blue]{
		*6((-HO)=-
			(-[:-30]N(-[6]ts)-[:30]-[::60]-[::60](-[2]O-[::-71]Et)(-[:30]O-[0]Et)
		-[::50,0.7]H)=-=-)
	}
	\arrow{->[\mbox{\color{red}2]}]}[,,red]
	\subscheme{
		\chemfig[red]{
			*6((-HO)=-(-[:-30]N(-[6]ts)-[:30]-[::60]-[::60](=[2]O)-[::50,0.7]H)=-=-)
		}
		\arrow{<=>}[-90,,red]
		\chemfig[red]{
			*6((-HO)=-(-[:-30]N(-[6]ts)-[:30]-[::60]=^[::60](-[2]OH)-[::50,0.7]H)=-=-)
		}
	}
	\arrow{->}[,,red]
	\chemfig[red]{
		*6((-HO)=-(*6(-N(-ts)---(-OH)-))=-=-)
	}
	\arrow{->[*{0}\mbox{\color{green}3]}]}[90,,green]
	\chemfig[green]{
		*6((-HO)=-(*6(-N(-ts)--=-))=-=-)
	}
	\arrow{->[*{0}\mbox{\color{magenta}4]}]}[90,1.75,magenta]
	\chemfig{
		*6((-HO)=-(*6(-N=-=-))=-=-)
	}
	\arrow(@c1.east--){->[\chemfig{
			-(-[::60])-[::-60]N(-[0]H)-[::-60](-[::-60])-[::60]
	} / \ch{EtOH}][\parbox{6.5cm}{
		{\color{blue}1] \textminus7\textdegree C, 4hrs}  \chemfig[blue]{H-[:30](=[2]O)-[:-30]=_[6]}\\
		{\color{red}2] 6N \ch{HCl} 20\textdegree C, 16hrs, 45\textdegree C 4hrs}\\
		{\color{green}3] \ch{KOH}, reflux, 24hrs}\\
		{\color{magenta}4] 5N \ch{HCl} to \pH=7, 0\textdegree C}
	}]}[,3.5]
\chemmove{
	\node at (-230pt,20pt) {I};
	\node at (-300pt,-170pt) {Ia};
	\node at (-300pt,-320pt) {Ib};
	\node at (-35pt,-240pt) {Ic};
	\node at (-35pt,-370pt) {Ic'};
	\node at (40pt,-320pt) {Id};
	\node at (40pt,-170pt) {Ie};
	\node at (40pt,30pt) {III};
	\node at (-75pt,-40pt) {II};
}
\schemestop
\end{document}