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IUPAC definition for denaturation (of a macromolecule)

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Description
English: The process of partial or total alteration of the native structure of a macromolecule resulting from the loss of tertiary or tertiary and secondary structure that is a consequence of the disruption of stabilizing weak bonds. Denaturation can occur when proteins and nucleic acids are subjected to elevated temperature or to extremes of pH, or to non-physiological concentrations of salt, organic solvents, urea or other chemical agents.
Date
Source International Union of Pure and Applied Chemistry (IUPAC)
Author International Union of Pure and Applied Chemistry (IUPAC)

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