File:Ijms-22-05850-g001-550 (1).webp
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neurofibrlmatosis
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| Description |
English: Figure 1. Molecular pathogenesis of NF1. NF1 codes for neurofibromin, which is a Ras-GTPase-activating protein (Ras-GAP). NF1 gene deficiency leads to Ras hyperactivation, which causes the subsequent activation of the AKT/mTOR and Raf/MEK/ERK pathways. ERK activates SYN1 modulating GABA release. Ras-GTP also activates Rac1 and Cdc42 pathways, leading to overactivation of PAK1. |
| Date | |
| Source | https://www.mdpi.com/1422-0067/22/11/5850 |
| Author | Tamura, R. |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 19:25, 28 February 2024 | | 417 × 550 (19 KB) | Ozzie10aaaa (talk | contribs) | Uploaded a work by Tamura, R. from https://www.mdpi.com/1422-0067/22/11/5850 with UploadWizard |
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