English: Figure 4. Therapeutic pathways in T-PLL. While alemtuzumab is the current frontline therapy, an improved understanding of T-PLL pathogenesis is leading to potentially targetable vulnerabilities. These include attempts to reinstate p53 function through MDM2 inhibitors as well as exploitation of faulty double strand break repair via PARP inhibitors, inhibition of TCR activation through ITK inhibitors as well as AKT/PI3K inhibitors, JAK inhibitors which inhibit cell growth and differentiation through the JAK-STAT pathway, BH3 mimetics to promote BAX and BAK mediated cell death, epigenetic approaches including hypomethylating agents and HDAC inhibitors, and novel antibody targeting e.g., CCR7. The illustration was created using Biorender.com and is adapted from previous review articles [47,72,73].