File:Image CausesofPopulationStructure.png
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DescriptionImage CausesofPopulationStructure.png |
English: A phylogenetic tree demonstrating the relationships between 38 inbred mouse strains using 140,000 Mouse HapMap SNPs. As shown in the tree, the strains cluster in two groups: classical inbred strains and wild-derived strains. The body weight phenotypes, obtained from the Mouse Phenome Database, of the strains is shown. Here, classical inbred strains have much higher body weight than do wild-derived strains. Many SNPs separate the two groups because of the long branch length. One such SNP is shown in the figure. Clearly the SNP is highly correlated with body weight. All of the SNPs that separate these two groups will have the same correlation. When we consider both the tree and the SNP, we can infer that the population structure may be driving this correlation and not an effect of the SNP on body weight. |
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Author | Lanasmartinphd |
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