File:Infant microbes and metabolites point to childhood neurodevelopmental disorders.pdf
Infant_microbes_and_metabolites_point_to_childhood_neurodevelopmental_disorders.pdf (0 × 0 pixels, file size: 16.56 MB, MIME type: application/pdf)
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DescriptionInfant microbes and metabolites point to childhood neurodevelopmental disorders.pdf |
English: This study has followed a birth cohort for over 20 years to find factors associated with neurodevelopmental disorder (ND) diagnosis. Detailed, early-life longitudinal questionnaires captured infection and antibiotic events, stress, prenatal factors, family history, and more. Biomarkers including cord serum metabolome and lipidome, human leukocyte antigen (HLA) genotype, infant microbiota, and stool metabolome were assessed. Among the 16,440 Swedish children followed across time, 1,197 developed an ND. Significant associations emerged for future ND diagnosis in general and for specific ND subtypes, spanning intellectual disability, speech disorder, attention-deficit/hyperactivity disorder, and autism. This investigation revealed microbiome connections to future diagnosis as well as early emerging mood and gastrointestinal problems. The findings suggest links to immunodysregulation and metabolism, compounded by stress, early-life infection, and antibiotics. The convergence of infant biomarkers and risk factors in this prospective, longitudinal study on a large-scale population establishes a foundation for early-life prediction and intervention in neurodevelopment. |
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Source | https://www.cell.com/cell/fulltext/S0092-8674(24)00238-1 |
Author | Angelica P. Ahrens, Tuulia Hyötyläinen, Joseph R. Petrone, Kajsa Igelström, Christian D. George, Timothy J. Garrett, Matej Orešič, Eric W. Triplett, and Johnny Ludvigsson |
doi:10.1016/j.cell.2024.02.035
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current | 02:35, 8 April 2024 | 0 × 0 (16.56 MB) | Koavf (talk | contribs) | Uploaded a work by Angelica P. Ahrens, Tuulia Hyötyläinen, Joseph R. Petrone, Kajsa Igelström, Christian D. George, Timothy J. Garrett, Matej Orešič, Eric W. Triplett, and Johnny Ludvigsson from https://www.cell.com/cell/fulltext/S0092-8674(24)00238-1 with UploadWizard |
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